{"id":1063,"date":"2017-04-11T00:28:28","date_gmt":"2017-04-11T00:28:28","guid":{"rendered":"http:\/\/moraeslab.com\/cmed\/?p=1063"},"modified":"2017-05-18T10:32:03","modified_gmt":"2017-05-18T10:32:03","slug":"icefish-chips-scaling-towards-microscale-human","status":"publish","type":"post","link":"https:\/\/moraeslab.com\/cmed\/icefish-chips-scaling-towards-microscale-human\/","title":{"rendered":"Icefish and chips: scaling towards a microscale human"},"content":{"rendered":"<p>Why has Joey been playing with an antarctic icefish for the last few years? \u00a0These unusual creatures have developed evolutionary adaptations that allow them to survive in harsh environmental conditions, and modelling these adaptations might be the key to designing a microphysiological &#8216;human&#8217; on a chip for drug discovery. Scaling presents a big practical problem in\u00a0connecting organ compartments together: how do we make sure the liver has sufficient volume to metabolize a drug dose delivered through the lung surface area, to treat a cancer tumor in the GI tract? \u00a0The icefish has developed natural adaptations to overcome critical transport limitations imposed by their surroundings, and Joe shows with experimental and analytical models that these &#8216;tricks&#8217; may be used to design physiologically scaled humans-on-chips. \u00a0Check out the <a href=\"http:\/\/moraeslab.com\/cmed\/publications\/\">publication <\/a>recently\u00a0out in\u00a0<em><a href=\"http:\/\/moraeslab.com\/cmed\/wp-content\/uploads\/2013\/11\/38_Technology_HoCDesign.pdf\">Technology<\/a><\/em>!<\/p>\n ","protected":false},"excerpt":{"rendered":"<p>Why has Joey been playing with an antarctic icefish for the last few years? \u00a0These unusual creatures have developed evolutionary adaptations that allow them to survive in harsh environmental conditions, and modelling these adaptations might be the key to designing<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-1063","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/posts\/1063","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/comments?post=1063"}],"version-history":[{"count":1,"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/posts\/1063\/revisions"}],"predecessor-version":[{"id":1064,"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/posts\/1063\/revisions\/1064"}],"wp:attachment":[{"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/media?parent=1063"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/categories?post=1063"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/tags?post=1063"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}