{"id":701,"date":"2014-05-12T15:34:38","date_gmt":"2014-05-12T15:34:38","guid":{"rendered":"http:\/\/moraeslab.com\/cmed\/?p=701"},"modified":"2014-05-15T19:38:45","modified_gmt":"2014-05-15T19:38:45","slug":"breaking-news-fracture-based-microfluidics","status":"publish","type":"post","link":"https:\/\/moraeslab.com\/cmed\/breaking-news-fracture-based-microfluidics\/","title":{"rendered":"Breaking news!  Fracture-based microfluidics"},"content":{"rendered":"<p>Fabricating dynamic microfluidic structures can be challenging. \u00a0In Byoung Choul and Chris&#8217; latest work, adjustable microfluidic channels with defined dimensions and positions can be created by simply stretching and\u00a0fracturing a multilayered material. \u00a0In this technique, a film of brittle silicone is sandwiched between two tough silicone layers, and stretched. \u00a0The modulus and toughness mismatch between the materials causes the brittle layer to fracture in a well-defined pattern. \u00a0The fracture forms an adjustable microfluidic channel, which is completely reversible: \u00a0it seems that breaking up is not\u00a0that hard to undo. \u00a0We used this technique to trap single cells within an adjustable microchannel, mechanically lyse them during channel collapse, and linearize the released nuclear chromatin for epigenetic analysis. \u00a0Please see <a title=\"Publications\" href=\"http:\/\/moraeslab.com\/cmed\/publications\/\">publication<\/a>s\u00a0for more information.<\/p>\n  <div class=\"otw-row\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Fabricating dynamic microfluidic structures can be challenging. \u00a0In Byoung Choul and Chris&#8217; latest work, adjustable microfluidic channels with defined dimensions and positions can be created by simply stretching and\u00a0fracturing a multilayered material. \u00a0In this technique, a film of brittle silicone<\/p>\n","protected":false},"author":2,"featured_media":694,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-701","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/posts\/701","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/comments?post=701"}],"version-history":[{"count":0,"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/posts\/701\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/media\/694"}],"wp:attachment":[{"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/media?parent=701"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/categories?post=701"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/tags?post=701"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}