{"id":789,"date":"2014-12-23T17:14:23","date_gmt":"2014-12-23T17:14:23","guid":{"rendered":"http:\/\/cmed.lab.mcgill.ca\/?p=789"},"modified":"2014-12-23T17:15:10","modified_gmt":"2014-12-23T17:15:10","slug":"3d-matrices-drive-migration-via-gradient-generating-mechanisms","status":"publish","type":"post","link":"https:\/\/moraeslab.com\/cmed\/3d-matrices-drive-migration-via-gradient-generating-mechanisms\/","title":{"rendered":"Hydrogel environments drive migration via gradient-generating mechanisms"},"content":{"rendered":"<p>Gradients of soluble factors are known to drive key cellular processes such as migration. \u00a0Establishing a soluble gradient can be done with microfluidics, but is a finicky process &#8211; accidental bumps can destroy a carefully-formed gradient. \u00a0If this is challenging to do under controlled conditions, how do gradients form in the chaos of the human body? \u00a0Using common microfabrication tools, Tai developed an ultra-simple 3D migration assay to probe this question in naturally-occuring hydrogel matrices.\u00a0We then experimentally demonstrated that migration of cancer cells may be driven by gradients that self-assemble as a result of vastly increased binding interactions in &#8216;sticky&#8217; 3D\u00a0hydrogels. \u00a0So not only do 3D environments influence cell function directly, they also shape\u00a0the signals provided to the cells themselves, adding a new level of complexity to 3D studies of biological systems. \u00a0For more information, see the full paper <a href=\"http:\/\/moraeslab.com\/cmed\/wp-content\/uploads\/2013\/11\/22_ActaBiomat14_3Dmigration.pdf\" target=\"_blank\">here<\/a>, or on\u00a0our <a title=\"Publications\" href=\"http:\/\/moraeslab.com\/cmed\/publications\/\">Publications<\/a>\u00a0page.<\/p>\n  <div class=\"otw-row\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Gradients of soluble factors are known to drive key cellular processes such as migration. \u00a0Establishing a soluble gradient can be done with microfluidics, but is a finicky process &#8211; accidental bumps can destroy a carefully-formed gradient. \u00a0If this is challenging<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-789","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/posts\/789","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/comments?post=789"}],"version-history":[{"count":0,"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/posts\/789\/revisions"}],"wp:attachment":[{"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/media?parent=789"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/categories?post=789"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/moraeslab.com\/cmed\/wp-json\/wp\/v2\/tags?post=789"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}