With apologies in advance for the massive number of puns we are about to inflict on the research world, Chris begins a new role as Highlights Editor for the RSC journal Integrative Biology! Check out the first of these bi-monthly reports of recent discoveries from labs that develop unique technological approaches to studying biological systems. This months’ highlight reports on integrating advanced imaging capabilities into microfluidic systems, to study biology without any pesky diffraction limitations in imaging resolution.